Traits & Carrier Status · Document 22 of 24
Cardiometabolic
Selected variants in Sample Subject's cardiometabolic risk landscape, across the 9p21, TCF7L2, and FTO loci. All values below are synthetic and for demonstration only.
3 findings
1 Tier 1
1 Tier 2
1 Tier 3
Reviewed 2026-01-15
Provenance
Data Provenance
verified chain
- Document
- Cardiometabolic
- Source assembly
- GRCh37 (hg19)
- Source file SHA-256
- 0000a1b2c3d4e5f6…4b5c6d7e
- Supersedes
- prior v1 · SHA 1111f0e9…
- Evidence sources
- GWAS Catalog, PubMed
- Access date
- 2026-01-15
Per-Gene Findings
Filter:
CDKN2B-AS1 — 9p21 Risk Allele Present
9p21 locus · coronary-artery-disease marker
GWAS CatalogTier 1
rs10757278
9:22,124,477
AG
rs10757278 is A/G — one copy of the 9p21 coronary-risk allele. The GWAS Catalog and cited literature record this CDKN2B-AS1 / 9p21 locus as a coronary-artery-disease association.
Source: GWAS Catalog 9p21 ↗ · PubMed PMID 17478679 ↗
TCF7L2 — Type-2-Diabetes Allele Present
Transcription factor 7-like 2 · glucose regulation
GWAS CatalogTier 2
rs7903146
10:114,758,349
CT
rs7903146 is C/T — one copy of the TCF7L2 type-2-diabetes risk allele. The GWAS Catalog records this variant among the strongest common type-2-diabetes associations.
Source: GWAS Catalog TCF7L2 ↗
FTO — Adiposity Locus Heterozygous
FTO alpha-ketoglutarate dioxygenase · body-mass marker
GWAS CatalogTier 3
rs9939609
16:53,820,527
TA
rs9939609 is T/A at the FTO adiposity locus; this sample carries one copy of the A allele. The GWAS Catalog records FTO associations with body-mass index.
Source: GWAS Catalog FTO ↗
Genotype Table
| rsID | chr:pos | Genotype | Gene | Significance |
|---|---|---|---|---|
rs10757278 | 9:22,124,477 | AG | CDKN2B-AS1 | Tier 1 |
rs7903146 | 10:114,758,349 | CT | TCF7L2 | Tier 2 |
rs9939609 | 16:53,820,527 | TA | FTO | Tier 3 |
Consult your prescribing clinician. This HelixlyAI report is a synthetic demonstration generated from a consumer DNA export. It is not a diagnosis, prescription, or substitute for professional medical advice. Do not start, stop, or change any treatment based on this document. Genotype is one of many factors influencing cardiometabolic risk.