Immunity & Allergy · Document 15 of 24
Allergy & Histamine
How Sample Subject's histamine-degradation and skin-barrier variants may relate to intolerance and allergy patterns. All values below are synthetic.
3 findings2 Tier 2Reviewed 2026-01-15
Provenance
Provider Alert
Considerations — Provider Ready
| Consideration | Gene / Genotype | Evidence | Recommendation | Source |
|---|---|---|---|---|
| Dietary histamine | AOC1 (DAO) ( rs0021101 GT) | Moderate | Reduced degradation — a supervised low-histamine trial may clarify symptoms. | PubMed ↗ |
| Antihistamine response | HNMT ( rs0021201 CT) | Limited | Altered intracellular clearance — monitor symptomatic response to therapy. | dbSNP ↗ |
Per-Gene Findings
Filter:
AOC1 (DAO) — Reduced Histamine Degradation
Diamine oxidase · gut histamine breakdown
ModerateTier 2
rs00211017:150,800,000GTHeterozygous genotype associated with reduced diamine-oxidase activity, the main enzyme degrading dietary histamine in the gut. May contribute to histamine-intolerance-type symptoms in some individuals.
Source: PubMed PMID 00021101 ↗ · dbSNP rs0021101 ↗
Historical contextEarlier panel reported this under the legacy gene symbol; current annotation uses the approved symbol at access date.
HNMT — Reduced Methylation Clearance
Histamine N-methyltransferase · intracellular clearance
LimitedTier 2
rs00212012:138,700,000CTVariant associated with modestly reduced HNMT activity, a secondary route of histamine clearance. Evidence for clinical impact in isolation is limited.
Source: dbSNP rs0021201 ↗
FLG — Skin-Barrier Variant
Filaggrin · epidermal barrier
LimitedTier 3
rs00213011:152,300,000CTCarrier of one barrier-associated allele, reported for transparency. Evidence is insufficient to support a recommendation from genotype alone.
Source: PubMed PMID 00021301 ↗
Genotype Table
| rsID | chr:pos | Genotype | Gene | Significance |
|---|---|---|---|---|
rs0021101 | 7:150,800,000 | GT | AOC1 | Tier 2 |
rs0021201 | 2:138,700,000 | CT | HNMT | Tier 2 |
rs0021301 | 1:152,300,000 | CT | FLG | Tier 3 |
Consult your prescribing clinician. This HelixlyAI report is a synthetic demonstration generated from a consumer DNA export. Every name, identifier, rsID, genotype, and citation shown is fictional. It is not a diagnosis or medical advice — do not start, stop, or change any medication or treatment based on this document.