Pharmacology · Document 06 of 24
Caffeine Metabolism
Sample Subject's caffeine clearance and sensitivity, read from CYP1A2 and AHR genotype. All values below are synthetic and for demonstration only.
2 findings
1 Tier 2
1 Tier 3
Reviewed 2026-01-15
Provenance
Data Provenance
verified chain
- Document
- Caffeine Metabolism
- Source assembly
- GRCh37 (hg19)
- Source file SHA-256
- 0000a1b2c3d4e5f6…4b5c6d7e
- Supersedes
- prior v1 · SHA 1111f0e9…
- Evidence sources
- PubMed, GWAS Catalog, dbSNP
- Access date
- 2026-01-15
Per-Gene Findings
Filter:
CYP1A2 — Slow Caffeine Metabolism
Cytochrome P450 1A2 · caffeine clearance
PubMedTier 2
rs762551
15:75,041,917
AC
The AC genotype carries one slow-metabolism CYP1A2 allele, which defines intermediate caffeine clearance — slower than the AA (rapid) genotype.
Source: PubMed PMID 16522833 ↗ · dbSNP rs762551 ↗
AHR — Caffeine-Consumption Locus
Aryl hydrocarbon receptor · CYP1A2 induction
GWASTier 3
rs4410790
7:17,284,577
CT
The CT genotype sits at the AHR caffeine-consumption locus, where AHR regulates CYP1A2 induction. This locus associates with habitual caffeine intake in genome-wide studies.
Source: GWAS Catalog AHR ↗ · dbSNP rs4410790 ↗
Genotype Table
| rsID | chr:pos | Genotype | Gene | Significance |
|---|---|---|---|---|
rs762551 | 15:75,041,917 | AC | CYP1A2 | Tier 2 |
rs4410790 | 7:17,284,577 | CT | AHR | Tier 3 |
Consult your prescribing clinician. This HelixlyAI report is a synthetic demonstration generated from a consumer DNA export. It is not a diagnosis, prescription, or substitute for professional medical advice. Do not start, stop, or change any medication based on this document. Genotype is one of many factors influencing drug response.