Immunity & Allergy · Document 16 of 24

Celiac (HLA-DQ)

Sample Subject's HLA haplotype context associated with celiac disease, read from the HLA-DQ2.5 and HLA-DQ8 tag variants. All values below are synthetic and for demonstration only.

2 findings 1 Tier 1 1 Tier 3 Reviewed 2026-01-15

Provenance

Data Provenance verified chain

Document: Celiac (HLA-DQ)
Source assembly: GRCh37 (hg19)
Source file SHA-256: 0000a1b2c3d4e5f6…4b5c6d7e
Supersedes: prior v1 · SHA 1111f0e9…
Evidence sources: ClinVar, PubMed, dbSNP
Access date: 2026-01-15

Per-Gene Findings

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HLA-DQA1 — DQ2.5 Tag Allele Present

HLA class II · celiac risk haplotype

ClinVarTier 1

rs2187668 6:32,605,884 CT

The CT genotype carries one HLA-DQ2.5 tag allele. HLA-DQ2.5 is the principal risk haplotype for celiac disease; nearly all celiac cases carry DQ2.5 or DQ8.

Source: ClinVar HLA-DQ2.5 ↗ · PubMed PMID 18509539 ↗

HLA-DQB1 — DQ8 Tag Allele Absent

HLA class II · haplotype completion

dbSNPTier 3

rs7454108 6:32,659,878 TT

The TT genotype shows the HLA-DQ8 tag allele is absent. Combined with rs2187668, this resolves the celiac-relevant haplotype as DQ2.5-positive, DQ8-negative.

Source: dbSNP rs7454108 ↗

Genotype Table

Variants evaluated in this document — synthetic
rsID	chr:pos	Genotype	Gene	Significance
`rs2187668`	6:32,605,884	CT	HLA-DQA1	Tier 1
`rs7454108`	6:32,659,878	TT	HLA-DQB1	Tier 3

Consult your prescribing clinician. This HelixlyAI report is a synthetic demonstration generated from a consumer DNA export. It is not a diagnosis, prescription, or substitute for professional medical advice. Do not start, stop, or change any medication based on this document. Genotype is one of many factors influencing drug response.