Methylation & Metabolism · Document 08 of 24

Folate & B12

Genotype context for Sample Subject's folate and B12 utilization, complementing the MTHFR / Methylation document. All values below are synthetic and for demonstration only.

3 findings 2 Tier 2 1 Tier 3 Reviewed 2026-01-15

Provenance

Data Provenance verified chain

Document: Folate & B12
Source assembly: GRCh37 (hg19)
Source file SHA-256: 0000a1b2c3d4e5f6…4b5c6d7e
Supersedes: prior v1 · SHA 1111f0e9…
Evidence sources: PubMed, dbSNP
Access date: 2026-01-15

Per-Gene Findings

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FUT2 — Secretor Status & B12

Fucosyltransferase 2 · vitamin B12 status

PubMedTier 2

rs602662 19:49,206,985 AG

The AG genotype carries one FUT2 secretor allele, which associates with higher circulating vitamin B12 relative to non-secretor genotypes.

Source: PubMed PMID 18776911 ↗ · dbSNP rs602662 ↗

TCN2 — Transcobalamin Transport

Transcobalamin 2 · cellular B12 delivery

PubMedTier 2

rs1801198 22:31,003,646 CG

The CG genotype carries one TCN2 P259R allele. This variant influences transcobalamin-bound B12 transport to tissues.

Source: PubMed PMID 11592820 ↗ · dbSNP rs1801198 ↗

MTHFD1 — Folate One-Carbon Pool

Methylenetetrahydrofolate dehydrogenase 1 · folate metabolism

dbSNPTier 3

rs2236225 14:64,442,127 GA

The GA genotype carries one MTHFD1 R653Q allele, which contributes to the folate one-carbon pool alongside the MTHFR variants reported in the methylation document.

Source: dbSNP rs2236225 ↗

Genotype Table

Variants evaluated in this document — synthetic
rsID	chr:pos	Genotype	Gene	Significance
`rs602662`	19:49,206,985	AG	FUT2	Tier 2
`rs1801198`	22:31,003,646	CG	TCN2	Tier 2
`rs2236225`	14:64,442,127	GA	MTHFD1	Tier 3

Consult your prescribing clinician. This HelixlyAI report is a synthetic demonstration generated from a consumer DNA export. It is not a diagnosis, prescription, or substitute for professional medical advice. Do not start, stop, or change any medication based on this document. Genotype is one of many factors influencing drug response.