Nutrition · Document 13 of 24

Iron / HFE

Sample Subject's hereditary hemochromatosis variants and iron-overload context, read from the HFE gene. All values below are synthetic and for demonstration only.

2 findings 2 Tier 1 Reviewed 2026-01-15

Provenance

Data Provenance verified chain

Document: Iron / HFE
Source assembly: GRCh37 (hg19)
Source file SHA-256: 0000a1b2c3d4e5f6…4b5c6d7e
Supersedes: prior v1 · SHA 1111f0e9…
Evidence sources: ClinVar, PubMed, dbSNP
Access date: 2026-01-15

Per-Gene Findings

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HFE — C282Y Allele Present

Homeostatic iron regulator · iron overload

ClinVarTier 1

rs1800562 6:26,093,141 GA

The GA genotype carries one HFE C282Y allele, the primary variant in hereditary hemochromatosis. A single allele confers carrier status for iron overload.

Source: ClinVar HFE C282Y ↗ · PubMed PMID 8696333 ↗

HFE — H63D Allele Present

Homeostatic iron regulator · iron overload

ClinVarTier 1

rs1799945 6:26,091,179 CG

The CG genotype carries one HFE H63D allele. In combination with C282Y, the C282Y/H63D compound genotype raises iron-overload risk above either single allele.

Source: ClinVar HFE H63D ↗ · dbSNP rs1799945 ↗

Genotype Table

Variants evaluated in this document — synthetic
rsID	chr:pos	Genotype	Gene	Significance
`rs1800562`	6:26,093,141	GA	HFE	Tier 1
`rs1799945`	6:26,091,179	CG	HFE	Tier 1

Consult your prescribing clinician. This HelixlyAI report is a synthetic demonstration generated from a consumer DNA export. It is not a diagnosis, prescription, or substitute for professional medical advice. Do not start, stop, or change any medication based on this document. Genotype is one of many factors influencing drug response.