Methylation & Metabolism · Document 09 of 24
Lipid Metabolism
Variants associated with Sample Subject's lipid handling and cardiometabolic context, centered on the APOE haplotype. All values below are synthetic and for demonstration only.
3 findings
2 Tier 2
1 Tier 3
Reviewed 2026-01-15
Provenance
Per-Gene Findings
Filter:
APOE — ε4-defining Allele Present
Apolipoprotein E · lipid transport
ClinVarTier 2
rs429358
19:45,411,941
TC
The TC genotype carries one APOE ε4-defining allele. The ε4 haplotype associates with higher LDL cholesterol than the ε3 reference.
Source: ClinVar APOE ↗ · PubMed PMID 24162737 ↗
APOE — ε2-defining Allele Absent
Apolipoprotein E · haplotype completion
ClinVarTier 2
rs7412
19:45,412,079
CC
The CC genotype shows the APOE ε2-defining allele is absent. Combined with rs429358, this resolves the APOE haplotype as ε3/ε4 for this sample.
Source: ClinVar APOE ↗
LPL — S447X Variant Absent
Lipoprotein lipase · triglyceride clearance
dbSNPTier 3
rs328
8:19,819,724
CC
The CC genotype shows the LPL S447X gain-of-function variant is absent. This sample carries the reference LPL allele at this position.
Source: dbSNP rs328 ↗
Genotype Table
| rsID | chr:pos | Genotype | Gene | Significance |
|---|---|---|---|---|
rs429358 | 19:45,411,941 | TC | APOE | Tier 2 |
rs7412 | 19:45,412,079 | CC | APOE | Tier 2 |
rs328 | 8:19,819,724 | CC | LPL | Tier 3 |
Consult your prescribing clinician. This HelixlyAI report is a synthetic demonstration generated from a consumer DNA export. It is not a diagnosis, prescription, or substitute for professional medical advice. Do not start, stop, or change any medication based on this document. Genotype is one of many factors influencing drug response.