Nutrition · Document 12 of 24
Vitamin D
Variants affecting Sample Subject's vitamin D binding and predicted baseline levels, read from GC, VDR, and CYP2R1 genotype. All values below are synthetic and for demonstration only.
3 findings
1 Tier 1
2 Tier 3
Reviewed 2026-01-15
Provenance
Data Provenance
verified chain
- Document
- Vitamin D
- Source assembly
- GRCh37 (hg19)
- Source file SHA-256
- 0000a1b2c3d4e5f6…4b5c6d7e
- Supersedes
- prior v1 · SHA 1111f0e9…
- Evidence sources
- GWAS Catalog, PubMed, dbSNP
- Access date
- 2026-01-15
Per-Gene Findings
Filter:
GC — Vitamin D Binding Protein
Group-specific component · vitamin D transport
GWASTier 1
rs2282679
4:72,608,383
AC
The AC genotype carries one GC low-level allele. This variant associates with lower vitamin D binding protein and lower circulating 25(OH)D.
Source: GWAS Catalog GC ↗ · PubMed PMID 20418485 ↗
VDR — FokI Site
Vitamin D receptor · receptor signaling
dbSNPTier 3
rs2228570
12:48,272,895
AG
The AG genotype carries one allele at the VDR FokI site. VDR encodes the vitamin D receptor that mediates downstream vitamin D signaling.
Source: dbSNP rs2228570 ↗
CYP2R1 — 25-Hydroxylase Variant
Cytochrome P450 2R1 · vitamin D activation
dbSNPTier 3
rs10741657
11:14,914,878
AG
The AG genotype carries one CYP2R1 variant at this locus. CYP2R1 performs the first hydroxylation step in vitamin D activation.
Source: GWAS Catalog CYP2R1 ↗ · dbSNP rs10741657 ↗
Genotype Table
| rsID | chr:pos | Genotype | Gene | Significance |
|---|---|---|---|---|
rs2282679 | 4:72,608,383 | AC | GC | Tier 1 |
rs2228570 | 12:48,272,895 | AG | VDR | Tier 3 |
rs10741657 | 11:14,914,878 | AG | CYP2R1 | Tier 3 |
Consult your prescribing clinician. This HelixlyAI report is a synthetic demonstration generated from a consumer DNA export. It is not a diagnosis, prescription, or substitute for professional medical advice. Do not start, stop, or change any medication based on this document. Genotype is one of many factors influencing drug response.